Clinical Trials

Human Studies on NMN

#	Title	Year	Dose
1	Nicotinamide mononucleotide (NMN) intake increases plasma NMN and insulin levels in healthy subjects FOCUS AREA INSULIN	2023	250mg
2	Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial FOCUS AREA ARTERIES	2023	250mg
3	Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study FOCUS AREA OBESITY	2023	2,000mg
4	The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial FOCUS AREA SAFETY EFFICACY	2022	300mg 600mg 900mg
5	Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study FOCUS AREA DIABETES	2022	250mg
6	Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals FOCUS AREA BLOOD TRIGLYCERIDES	2022	300mg
7	Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women FOCUS AREA SAFETY	2022	1,250mg
8	Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial FOCUS AREA METABOLISM ARTERIES	2022	250mg
9	Clinical evaluation of changes in biomarkers by oral intake of NMN FOCUS AREA BIOMARKERS EFFICACY	2022	300mg
10	Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men FOCUS AREA MUSCLE FUNCTION MEN	2022	250mg
11	A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults FOCUS AREA SAFETY EFFICACY	2022	300mg
12	Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women FOCUS AREA INSULIN WOMEN	2022	250mg
13	Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects FOCUS AREA SAFETY EFFICACY	2022	250mg
14	Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study FOCUS AREA SLEEP QUALITY FATIGUE	2022	250mg
15	MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults FOCUS AREA EFFICACY	2022	1,000mg
16	Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study FOCUS AREA AEROBIC CAPACITY	2021	1,200mg
17	Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men FOCUS AREA EFFICACY	2020	500mg

Human Studies on Resveratrol

#	Title	Year	Dose
1	Resveratrol and Vascular Health: Evidence from Clinical Studies and Mechanisms of Actions FOCUS AREA CARDIOVASCULAR	2024	Varies
2	Unraveling the Therapeutic Efficacy of Resveratrol in Alzheimer’s Disease: An Umbrella Review FOCUS AREA ALZHEIMER'S	2023	Varies
3	Resveratrol for Inflammatory Bowel Disease in Preclinical Studies: A Systematic Review and Meta-Analysis FOCUS AREA INFLAMMATORY BOWEL DISEASE	2023	Varies
4	The Therapeutic Potential of Resveratrol: A Review of Clinical Trials FOCUS AREA CANCER	2023	Varies
5	Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review FOCUS AREA MULTIFACETED	2022	Varies
6	Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Clinical Trials FOCUS AREA MULTIFACETED	2022	Varies
7	The Role of Resveratrol in Neurogenesis: A Systematic Review FOCUS AREA NEUROGENESIS	2022	Varies
8	Resveratrol in the Treatment of Diabetes Mellitus: A Review FOCUS AREA DIABETES	2022	Varies
9	Exploring the Anti-Inflammatory Effects of Resveratrol in Chronic Diseases FOCUS AREA ANTI-INFLAMMATORY	2021	Varies
10	Resveratrol as a Potential Therapeutic Agent for Neurodegenerative Diseases FOCUS AREA NEURODEGENERATIVE DISEASES	2021	Varies

Human Studies on Apigenin

#	Title	Year	Dose
1	Apigenin Protects Against Cognitive and Neurobehavioural Dysfunction: A Systematic Review of Preclinical Investigations FOCUS AREA NEUROPROTECTION	2024	25mg/kg
2	Experimental Evidence for Anti-Metastatic Actions of Apigenin: A Mini Review FOCUS AREA CANCER	2023	Varies
3	Apigenin in Cancer Prevention and Therapy: A Systematic Review and Meta-Analysis FOCUS AREA CANCER	2023	Varies
4	Apigenin-Loaded Stealth Liposomes: Development and Pharmacokinetic Studies for Enhanced Plasma Retention of Drug in Cancer Therapy FOCUS AREA PHARMACOKINETICS	2023	Varies
5	The Beneficial Role of Apigenin Against Cognitive and Neurobehavioural Dysfunction: A Systematic Review FOCUS AREA NEUROPROTECTION	2023	Varies
6	The Therapeutic Potential of Apigenin FOCUS AREA MULTIFACETED	2023	Varies
7	Apigenin and Its Dermatological Applications: A Comprehensive Review FOCUS AREA DERMATOLOGY	2022	Varies
8	Apigenin: A Natural Molecule at the Intersection of Sleep and Aging FOCUS AREA SLEEP	2022	Varies
9	The Effects of Apigenin in the Treatment of Diabetic Nephropathy FOCUS AREA DIABETIC NEPHROPATHY	2022	Varies
10	Exploring the Role of Apigenin in Neuroinflammation FOCUS AREA NEUROINFLAMMATION	2021	Varies

Human Studies on Berberine

#	Title	Year	Dose
1	Efficacy and Safety of HIMABERB® Berberine on Glycemic Control in Patients with Prediabetes: A Double-Blind, Placebo-Controlled, Randomized Pilot Trial FOCUS AREA INSULIN	2024	500mg
2	Berberine for the Treatment of Non-Alcoholic Fatty Liver Disease: A Meta-Analysis and Systematic Review FOCUS AREA LIVER DISEASE	2023	1000mg
3	Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials FOCUS AREA METABOLIC DISORDERS	2023	1500mg
4	Therapeutic Application of Berberine: A Consolidated Review FOCUS AREA ANTICANCER	2023	500mg
5	Berberine in the Treatment of Diabetes Mellitus: A Review FOCUS AREA DIABETES	2022	300mg
6	Clinical Evaluation of Berberine’s Effects on Obesity and Hyperlipidemia: A Double-Blind, Placebo-Controlled Study FOCUS AREA OBESITY	2022	600mg
7	Berberine’s Impact on Cardiovascular Health: Preclinical and Clinical Trials Review FOCUS AREA CARDIOVASCULAR	2022	1000mg
8	Safety and Efficacy of Berberine in Managing Blood Lipids: A Comprehensive Review FOCUS AREA SAFETY	2022	300mg
9	Neuroprotective and Cognitive Benefits of Berberine: A Clinical Review FOCUS AREA NEUROPROTECTION	2021	500mg
10	Berberine as an Anti-Inflammatory Agent in Chronic Diseases: Systematic Review FOCUS AREA INFLAMMATION	2021	750mg

Preliminary Studies for NMNH

#	Title	Year	Dose
1	Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth FOCUS AREA NAD+ CELL GROWTH GLYCOLYSIS	2021	-
2	Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice FOCUS AREA NAD+ METABOLISM	2021	-