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Science-Page---Our-Vision

The Challenge of a Short Healthspan

While advancements in science have steadily increased lifespan, they haven’t extended healthspan, which is the period of life spent in good health. Ageing remains the biggest risk factor for poor health, leading to chronic conditions that affect the quality of life in later years.

We envision a future where people maintain independence, enjoy their favourite activities and spend quality time with loved ones well into their life.

Though many face declining vitality, recent scientific breakthroughs offer hope for ageing with energy, flexibility, and a continued sense of wellbeing.

The Hallmarks of Ageing

As we age, the structure, function and processes within our cells change. The scientific community widely recognises several key factors, known as the “Hallmarks of Ageing”:

Genomic
Instability
Epigenetic

Alterations
Telomere

Attrition
Mitochondria
Dysfunction
Altered Intercellular
Communication
Stem Cell
Exhaustion
Cellular

Senescence
Deregulated
Nutrient Sensing
Loss of

Proteostasis
Disabled

Autophagy
Inflammaging
Microbiome

Dysbiosis

These hallmarks manifest externally through changes in skin elasticity, hair colour and pigmentation, and internally through issues like poor sleep, declining energy, altered autophagy, NAD+ levels and telomere structure.

Tailored Support for Biological Age

At Elevate BleuTM, we recognise that support needs differ at various stages of biological age. Our premium products are designed to provide targeted support based on your unique biological age or lifestyle factors. Our formulations support the ageing process in ways previous generations did not have access to, offering personalised solutions to enhance healthspan and improve overall wellbeing.

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Sciece-Page---Tailored

Traditionally, there are eleven body systems:

Nervous

System
Skeletal

System
Circulatory

System
Integumentary

System
Endocrine

System
Digestive

System
Respiratory

System
Immune

System
Muscular

System
Renal

System
Reproductive

System

In addition to these eleven systems, supporting your cellular health is the foundation for overall healthy ageing. By taking care of your cells, you support all eleven other body systems, promoting comprehensive wellbeing.

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NAD+ Levels

  • NAD+ levels with precursor supplementation
  • Natural NAD+ levels with age

nad+

age

NAD+ and its significance explained

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell of the body that plays a crucial role in energy production and maintaining cellular health.[1] The coenzyme is scientifically proven to boost the activity of all seven sirtuins.[2] When NAD+ levels are high, sirtuins become more active, supporting cellular function.[3]

NAD+ helps convert nutrients into energy and is responsible for critical cell functions, including cell growth, metabolism, DNA repair, and important biological processes.[4]

As we age, the natural level of NAD+ in our body declines. Evidence demonstrates that NAD+ levels reduce by approximately 50% every 20 years.[5] This decline is linked to reduced energy, cellular function and signs of ageing. [6]

Although NAD+ can be boosted by diet,[7] diet alone will not completely revive the inadequate levels. Elevate’s NAD+ boosting supplements are designed to support replenishing adequate NAD+ levels in the body.

Why not take NAD+ directly?

Direct NAD+ supplementation is inefficient because NAD+ molecules are too large to easily cross cell membranes. In contrast, NMN can easily enter cells and, once inside, is quickly converted to NAD+, making it a more effective way to boost NAD+ levels in the body.

  1. Bieganowski, P, & Brenner, C 2004 ‘Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans’, Cell, vol. 117, no. 4, pp. 495-502.
  2. Sinclair, D & LaPlante, M 2019, Lifespan: Why We Age – and Why We Don’t Have To, Harper Collins Publishers, Dublin, Ireland, pp. 133-135.
  3. Verdin, E 2014, ‘Sirtuins, NAD+, and Aging’, Trends in Endocrinology & Metabolism, vol. 25, no. 3, pp. 219-226.
  4. ‘Recent research into nicotinamide mononucleotide and ageing’ 2022, Natural Portfolio, vol. 1, pp. 1.
  5. Shade, C 2020, ‘The Science Behind NMN – A Stable, Reliable NAD+ Activator and Anti-Aging Molecule’, Integrative Medicine, vol. 19, no. 1.
  6. ‘Recent research into nicotinamide mononucleotide and ageing’ 2022, Natural Portfolio, vol. 1, pp. 1.
  7. Sinclair, D & LaPlante, M 2019, Lifespan: Why We Age – and Why We Don’t Have To, Harper Collins Publishers, Dublin, Ireland, pp. 135.

Pure NMN

NMN (Nicotinamide Mononucleotide) is a derivative of Vitamin B3 that directly boosts NAD+ production, a critical molecule for energy and cellular health.[1]

NMN is converted into NAD+ through a single enzymatic step within cells.[2]

In contrast, NR (Nicotinamide Riboside), another NAD+ booster, must first be converted into NMN through phosphorylation before becoming NAD+, making it a two-step process.

Research has also identified the Slc12a8 gene, which allows NMN to be directly absorbed into cells, making it a more efficient and stable option for increasing NAD+ levels.[3] 

  1. Grozio, A, Mills, K. F, Yoshino, J, Bruzzone, S, Sociali, G, Tokizane, K, & Imai, S. I 2020, ‘Nicotinamide mononucleotide: Exploration of diverse therapeutic applications of a potential molecule’, Biomolecules, vol. 10, no. 3.
  2. Yoshino, J, Mills, K. F, Yoon, M. J, & Imai, S. I. 2011, ‘Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice’, Cell Metabolism, vol. 14, no. 4, p. 528-536.
  3. Grozio, A, Mills, K. F, Yoshino, J, Bruzzone, S, Sociali, G, Tokizane, K, & Imai, S. I 2020, ‘Nicotinamide mononucleotide: Exploration of diverse therapeutic applications of a potential molecule’, Biomolecules, vol. 10, no. 3.

Super NMNH

Dihydronicotinamide Mononucleotide (NMNH) is a reduced form of NMN, which shows clinical promise in supporting a significant surge in NAD+ levels and a faster, longer lasting and more effective absorption than any other NAD+ booster on the global market.[1] In other words, Super NMNH is potentially more potent, thus more effective than Pure NMN.[2]

01 /04

Super NMNH

20 Hrs Steady NAD+ Increase 

The dynamics of Super NMNH (Reduced NMN) have been captivating scientists. Upon supplementation, Super NMNH rapidly elevated NAD+ levels within just 15 minutes at an unprecedented pace. What sets NMNH apart is its ability to sustain this elevation, with NAD+ levels remaining 2-fold for up to 20 hours. This contrasts sharply with the plateau observed with NMN.[3]

02 /04

Super NMNH

Multi-Tissue NAD+ Influence, 5 Organs

NMNH (Reduced NMN)’s impact reverberates across various tissues, surpassing the effectiveness of NMN. Notably, NMNH triggered significant increases in NAD+ levels within vital organs such as the liver and kidney, signalling its potential for comprehensive cellular support. The brain, muscle, brown adipose tissue, and heart—all critical hubs of biological activity—also experienced heightened NAD+ levels, a feat not replicated by NMN.[4]

03 /04

Super NMNH

Clinical studies are currently being conducted on a larger scale, to validate Super NMNH’s efficacy against a wide range of health-related benefits including cardio protection, neuroprotection and liver protection.

Whilst Super NMNH does not have as much publicly available data as Pure NMN, the full extent of Super NMNH’s potential and additional clinical verification of these claims is being investigated through ongoing, extensive clinical studies on humans. To be notified of the latest peer-reviewed publications please click here to join our mailing list.

SuperNMNH-Product-Photo
NMNH-Molecular-Structure
04 /04
  1. Zapata-Pérez, R, Tammaro, A, Schomakers, B.V., Scantlebery, A. M. L, Denis, S, Elfrink, H. L, Giroud-Gerbetant, J, Cantó, C, López-Leonardo, C, McIntyre, R. L, van Weeghel, M, Sánchez-Ferrer, Á & Houtkooper, R. H 2021, ‘Reduced Nicotinamide Mononucleotide is a New Potent NAD+ Precursor in Mammalian Cells and Mice,’ The FASEB Journal, vol. 35, no. 4.
  2. Zapata-Pérez, R, Tammaro, A, Schomakers, B.V., Scantlebery, A. M. L, Denis, S, Elfrink, H. L, Giroud-Gerbetant, J, Cantó, C, López-Leonardo, C, McIntyre, R. L, van Weeghel, M, Sánchez-Ferrer, Á & Houtkooper, R. H 2021, ‘Reduced Nicotinamide Mononucleotide is a New Potent NAD+ Precursor in Mammalian Cells and Mice,’ The FASEB Journal, vol. 35, no. 4
  3. Zapata-Pérez, R, Tammaro, A, Schomakers, B.V., Scantlebery, A. M. L, Denis, S, Elfrink, H. L, Giroud-Gerbetant, J, Cantó, C, López-Leonardo, C, McIntyre, R. L, van Weeghel, M, Sánchez-Ferrer, Á & Houtkooper, R. H 2021, ‘Reduced Nicotinamide Mononucleotide is a New Potent NAD+ Precursor in Mammalian Cells and Mice,’ The FASEB Journal, vol. 35, no. 4.
  4. Zapata-Pérez, R, Tammaro, A, Schomakers, B.V., Scantlebery, A. M. L, Denis, S, Elfrink, H. L, Giroud-Gerbetant, J, Cantó, C, López-Leonardo, C, McIntyre, R. L, van Weeghel, M, Sánchez-Ferrer, Á & Houtkooper, R. H 2021, ‘Reduced Nicotinamide Mononucleotide is a New Potent NAD+ Precursor in Mammalian Cells and Mice,’ The FASEB Journal, vol. 35, no. 4.

Pure NMN versus Super NMNH

Pure NMN and Super NMNH both belong to the house of NAD+ boosting precursors, that support replenishing NAD+ levels in the body.[1]

While the two acronyms (NMN and NMNH) might appear similar and both belong to the house of NAD+ boosters, they refer to distinct compounds with varying roles and implications in the realm of health and biology.

To be notified of the latest peer-reviewed publications, please join our mailing list.

  1. Liu, Y, Luo, C, Li, T, Zhang, W, Zong, Z, Liu, X & Deng, H (2021), ’Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+ and Supresses Glycolysis, the TCA Cycle, and Cell Growth’, Journal of Proteome Research, vol. 20, no. 5, pp. 2596-2606.

Pure Resveratrol

Pure Resveratrol is a polyphenolic compound belonging to the polyphenols’ stilbenoids group.[1] Pure Resveratrol is naturally occurring and can be found in more than 70 plant species including red grapes, berries, peanuts and even red wine.[2]

Resveratrol was first recognised for its anti-cancer activity in 1997, and since then, it has paved the way for longevity supplements.[3] As a dietary supplement, studies demonstrate promising results that Pure Resveratrol may increase DNA repair and cell renewal.

  • Cardiovascular health:
    Pure Resveratrol supports cardiovascular health by improving endothelial function, reducing blood pressure, and lowering LDL cholesterol levels. These effects contribute to a lower risk of heart disease.[4]
  • Antioxidant Protection:
    Pure Resveratrol acts as an antioxidant, helping to neutralize harmful free radicals that can damage cells and contribute to ageing processes.[5]
  • Anti-inflammation:
    Chronic inflammation is associated with various age-related diseases. Pure Resveratrol has demonstrated anti-inflammatory properties that may help reduce inflammation and its negative effects on health.[6]
  • Neuroprotection:
    Due to its multiple neuroprotection mechanisms, Pure Resveratrol can be used to treat neurological diseases, including Alzheimer’s Disease.[7]
  1. Salehi, B, Mishra, A, Nigam, M, Sener, B, Kilic, M, Sharifi-Rad, M, Fokou, P, Martins, N & Sharifi-Rad, J 2018,‘Resveratrol: A Double-Edged Sword in Health Benefits’, Biomedicines, vol. 6. no. 3, pp. 91.
  2. Salehi, B, Mishra, A, Nigam, M, Sener, B, Kilic, M, Sharifi-Rad, M, Fokou, P, Martins, N & Sharifi-Rad, J 2018, ‘Resveratrol: A Double-Edged Sword in Health Benefits’, Biomedicines, vol. 6. no. 3, pp. 91.
  3. Meng, X, Zhou, J, Zhao, C, Gan, R & Li, H 2020, ’Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review’, Foods, vol. 9, no. 3.
  4. Timmers, S, Konings, E, Bilet, L, Houtkooper, R, Weijer, T, Goossens, G, Hoeks, J, Krieken, S, Ryu, D, Kersten, S, Moonen-Kornips, E, Hesselink, M, Kunz, I, Schrauwen-Hingerling, V, Blaak, E, Auwerx, J & Schrauwen, P 2011, ‘Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans’, Cell Metabolism, vol. 14, no. 5, pp. 612-622.
  5. Sarubbo, F, Esteban, S, Miralles, A & Moranta, D 2018, ’Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging’, Curr Neuropharmacol, vol. 16, no. 2, pp. 126-136.
  6. Salehi, B, Mishra, A, Nigam, M, Sener, B, Kilic, M, Sharifi-Rad, M, Fokou, P, Martins, N & Sharifi-Rad, J 2018, ‘Resveratrol: A Double-Edged Sword in Health Benefits’, Biomedicines, vol. 6. no. 3, pp. 91.
  7. Rahman, M, Akter, R, Bhattacharya, T, Abdel-Daim, M, Alkahtani, S, Arafah, M, Al-Johani, N, Alhoshani, N, Alkeraishan, N, Alhenaky, A, Abd-Elkader, O, El-Seedi, H, Kaushik, D & Mittal, V 2020, ‘Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer’s Disease’, Frontiers, vol. 11. 

Pure Apigenin

Pure Apigenin is a naturally occurring polyphenol from the flavonoid group, which is the largest class of polyphenols.[1] This bioactive compound is commonly found in various foods, especially in chamomile, parsley and celery. As a dietary supplement, Apigenin has show promise in effects on brain health and function.[2]

Research suggests that it supports brain health by promoting neurogenesis and protecting against oxidative stress.[3]

Additionally, Apigenin has calming properties, helping to reduce anxiety, promote relaxation and improve sleep quality, making it a popular natural option for enhancing mental and emotional wellbeing.[4]

  • Brain Health:
    Pure Apigenin has been found to have neuroprotective properties that may benefit brain health and function. Research has shown that Pure Apigenin can protect neurons from damage and reduce neuroinflammation.[5]
  • Stress reduction effects:
    Cortisol is a hormone released in response to stress. High levels of cortisol over prolonged periods can lead to various health issues, including chronic stress. Pure Apigenin has been shown to modulate the release of cortisol, thereby helping to reduce stress levels.[6]
  • Relaxation & Sleep Quality:
    Found in chamomile, Pure Apigenin contributes to the calming effects of chamomile tea. It binds to benzodiazepine receptors in the brain, which can help reduce anxiety and promote relaxation and sleep.[7]
  • Anti-Cancer Protection:
    Pure Apigenin has shown promise in the prevention and treatment of various cancers. Studies have highlighted its ability to induce apoptosis (programmed cell death) and inhibit the proliferation of cancer cells.[8]
  1. Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
  2. Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
  3. Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
  4. Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
  5. Charriere, K, Schneider, V, Perrignon-Sommet, M, Lizard, G, Benani, A, Jacquin-Piques, A & Vejux, A 2024, ‘Exploring the Role of Apigenin in Neuroinflammation: insights and Implications’, Pub Med Central, vol. 25, no. 9.
  6. Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
  7. Gazola, A, Gosta, G, Castellanos, L, Ramos, F, Reginatto, F, de Lima, T, Schenkel, E 2015, ‘Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from Passiflora quadrangularis pericarp’, Revista Brasileira de Farmacogenosia, vol. 25, no. 3.
  8. Cao, H. H., et al. “Apigenin induced apoptosis of human breast carcinoma MCF-7 cells through mitochondria- and caspase-3-dependent pathways.” Anticancer Drugs, vol. 22, no. 3, 2011, pp. 286-297

Pure Berberine

Pure Berberine is an alkaloid, a class of organic compounds known for their significant pharmacological effects on the human body.[1] It is primarily extracted from the roots, rhizomes, stems and bark of various plant species, including turmeric trees and barberry. Berberine has a long history of use in traditional medicine, particularly in Chinese medicine, where it has been valued for centuries for its therapeutic properties.[2]

In modern times, Berberine has gained prominence as a health supplement, supported by scientific research showing its benefits in weight management. It works by activating ken enzymes that regulate metabolism, improving insulin sensitivity and supporting healthy blood sugar levels.[3]

Additionally Berberine is being studied for its potential in improving heart health, reducing chloresterol and supporting gut health, making it a versatile supplement with a broad range of health benefits.[4]

  • Blood sugar regulation:
    Pure Berberine has been shown to improve insulin sensitivity and lower blood glucose levels. It activates AMP-activated protein kinase (AMPK), a key regulator of cellular energy balance, which can help manage type 2 diabetes.[5]
  • Weight loss:
    Studies suggest that Pure Berberine may help with weight loss by improving metabolic functions and reducing body fat. It also helps regulate hormones related to fat storage and appetite.[6]
  • Metabolism Support:
    Pure Berberine can enhance fat burning and reduce the production of new fat cells, aiding in weight management.[7]
  • Cardiovascular Health: 
    Pure Berberine has been shown to improve cholesterol levels, which can contribute to better heart health.[8]
  1. Tillhon, M, Ortiz, L, Lombardi, P & Scovassi, A 2012, ‘Berberine: New perspectives for old remedies’, Biochemical Pharmacology, vol. 84, no. 10, pp. 1260-1267.
  2. Prajwala, B, Raghu, N, Gopennath, TS, Shanmukhappa, B, Karthikeyan, M, Ashok, G, Ranjith, M, Srinivasan, V & Basalingappa, K 2020, ‘Berberine And Its Pharmacology Potential: A Review’, European Journal of Biomedical And Pharmaceutical Science, vol. 7, no. 5, pp. 115-123.
  3. Ye, Y, Liu, X, Wu, N, Han, Y, Wang, J, Yu, Y & Chen, Q 2021, ‘Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials’, Frontiers in Pharmacology, vol. 12.
  4. Ye, Y, Liu, X, Wu, N, Han, Y, Wang, J, Yu, Y & Chen, Q 2021, ‘Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials’, Frontiers in Pharmacology, vol. 12.
  5. Yin, J, Xing, H & Ye, J 2008, ‘Efficacy of Berberine in Patients with Type 2 Diabetes Mellitus’, Metabolism Clinical and Experimental, vol. 57, no. 5, pp. 712-717.
  6. Kong, W, Wei, J, Abidi, P, Lin, M, Inaba, S, Li, C, Wang, Y, Wang, Z, Si, S, Pan, H, Wang, S, Wu, J, Wang, Y, Li, Z, Liu, J & Jiang, J 2004, ’Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins’, Nature Medicine, vol. 10, pp. 1344-1351.
  7. Hu, X, Zhang, Y, Xue, Y, Zhang, Z & Wang, J 2018, ‘Berberine is a potential therapeutic agent for metabolic syndrome via brown adipose tissue activation and metabolism regulation’, American Journal of Translational Research, vol. 16, no. 9. 
  8. Kong, W, Wei, J, Abidi, P, Lin, M, Inaba, S, Li, C, Wang, Y, Wang, Z, Si, S, Pan, H, Wang, S, Wu, J, Wang, Y, Li, Z, Liu, J & Jiang, J 2004, ’Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins’, Nature Medicine, vol. 10, pp. 1344-1351.

120+ years of scientific research on NAD+

1909

NAD+ was discovered by British biochemists Arthur Harden and William John Young, whilst they were investigating alcoholic fermentation in yeast. Harden and Young named the compound cozymase, now known as NAD+.[1]
1909

1929

Hans von Euler-Chelpin purified the NAD+ molecule, and discovered the initial insights into the chemical structure and characteristics of the co-factor essential for facilitating fermentation reactions. Von Euler-Chelpin and Harden were awarded the Nobel Prize for their pioneering research into fermentation.[2]

1929

1936

Through his investigations into fermentation reactions, Otto Heinrich Warburg discovered that NAD+ is crucial for a specific type of chemical reaction known as hydride transfer. Hydride reactions play vital roles in cellular metabolism and various other chemical processes essential for sustaining life.[3]
1936

1938

Conrad Elvehjem identified that NAD+ was able to cure black tongue disease in dogs, the canine equivalent of pellagra,[4] which is a systemic disease caused by Vitamin B3 (niacin) deficiency.[5]
1938

1948

Arther Kornberg isolated all the components required for a NAD+-generating reaction from yeast cells and assembled them in an experimental configuration to illustrate their role in NAD+ production. Kornberg’s experiments marked the initial demonstration of the cellular chemical reaction responsible for converting the precursor molecule Nicotinamide Mononucleotide (NMN) into NAD+.[6]
1948

1980

Austrian Graz University Professor, George Birkmayer, from the Department of Medicinal Chemistry, first applied the reduced form of NAD+ in disease treatment.[7]
1980

2004

Charles Brenner revealed that a form of Vitamin B3, known as Nicotinamide Riboside (NR) was a crucial precursor (essentially a building block) of NAD+. Brenner identified NR was detected in small amounts in foods, such as milk, and found that it could extend life expectancy.[8] This was the turning point where nutraceuticals became a means of boosting NAD+ levels and NR was sold by the ton each month.[9]
2004

2004

Whilst studying NMN, Dr. David Sinclair determined that it was detected in small amounts in foods such as green vegetables and berries. Along with peers, Dr. Sinclair detected that within the body, NR is converted into NMN, which is then converted into NAD+.[10]
2004

2011

Dr. Shin-ichiro Imai demonstrated that NMN could treat symptoms of type-2 diabetes in mature mice, by restoring NAD+ levels.[11] Other labs showed that NMN can reduce mitochondrial diseases, neurodegeneration and kidney damage.[12]
2011

2018

The World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time, added aging. [R] The classification of ‘aging as a disease’ paved the way for new research into novel therapeutics like NAD+ boosting supplementation, to delay or reverse age-related illnesses.

2018

2019

Harvard Professor, Dr David Sinclair’s book ‘Lifespan’ is published, drawing much global attention on the benefits of boosting NAD+ levels to reduce age related disease. [R]

2019

2021

Due to public interest, and growing evidence showing potential for therapeutic applications, the volume of human clinical trials on NAD+ boosting supplements increases significantly.[3]
2021

2022

The largest clinical trial on NMN to date was published showing NAD+ level increasing by 38% after 60 days of supplementation.[13]
2022

2023

The safety and efficacy of NMN to boost NAD+ continued and was validated by various global institutions [13] Additionally, Nicotinamide Dihydronucleotide (NMNH) a reduced form of NMN, showed great clinical promise in studies in mice [14]
2023

2024

NMN continues to be studied globally for its myriad of benefits [13] whilst NMNH is in human clinical trials [14]
2024
  1. Sinclair, D & LaPlante, M 2019, Lifespan: Why We Age – and Why We Don’t Have To, Harper Collins Publishers, Dublin, Ireland, pp. 134.
  2. von Euler-Chelpin, H 1930, ‘Fermentation of Sugars and Fermentative Enzymes’, Nobel Lecture, Stockholm, Sweden.
  3. Pyridin, C. W & Warburg, O 1936, ‘Der wasserstoffübertragende Bestandteil von Gärungsfermenten (translated: The hydrogen-transferring component of fermentation enzymes)’, Helvetica Chimica Acta, vol. 19, no. 1, p. 79-88.
  4. Elvehjem, C. A, et al 1974, ‘The Isolation and Identification of the Anti-Black Tongue Factor’, Nutritional Reviews, vol. 32, no. 2, p. 48-50.
  5. Sinclair, D & LaPlante, M 2019, Lifespan: Why We Age – and Why We Don’t Have To, Harper Collins Publishers, Dublin, Ireland, pp. 134.
  6. Kornberg, A 1948, ‘The participation of inorganic pyrophosphate in the reversible enzymatic synthesis of diphosphopyridine nucleotide’, J Biol Chem, vol. 176, no. 3, pp. 1475.
  7. Yu, J 2024, The Third Generation Super NAD+ Booster, pamphlet.
  8. Bieganowski, P, et al 2004, ‘Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans’, Cell, vol. 117, no. 4, pp. 495-502.
  9. Sinclair, D & LaPlante, M 2019, Lifespan: Why We Age – and Why We Don’t Have To, Harper Collins Publishers, Dublin, Ireland, pp. 135.
  10. Sinclair, D & LaPlante, M 2019, Lifespan: Why We Age – and Why We Don’t Have To, Harper Collins Publishers, Dublin, Ireland, pp. 135.
  11. Sinclair, D & LaPlante, M 2019, Lifespan: Why We Age – and Why We Don’t Have To, Harper Collins Publishers, Dublin, Ireland, pp. 136.
  12. Sinclair, D & LaPlante, M 2019, Lifespan: Why We Age – and Why We Don’t Have To, Harper Collins Publishers, Dublin, Ireland, pp. 136.
  13. Clinical Trials